The Effects of Vitamin D Supplementation on Vertigo and Tinnitus in Patients with Meniere’s Disease: A Randomized Clinical Trial

Abstract

Background: The present study aimed to evaluate the impact of vitamin D supplementation as an adjuvant therapy on tinnitus and vertigo in individuals diagnosed with Meniere’s disease. Methods: The study was conducted from November 2021 to October 2022 at Tehran University Hospital, Tehran, Iran. This clinical trial involved 60 individuals diagnosed with Meniere’s disease and vitamin D deficiency. Participants were randomly allocated to receive either vitamin D (50,000 IU weekly) or a placebo for eight weeks. The study assessed the frequency, intensity, and duration of vertigo attacks, as well as several measures of dizziness and tinnitus, both before and after the intervention. Results: No significant change was observed in the number of vertigo attacks (P = 0.85), the duration (P = 0.52), or the severity of vertigo (P = 0.33) in the vitamin D group compared to the placebo group at the end of the trial. Additionally, vitamin D supplementation did not significantly affect the results of various dizziness and tinnitus indices at the study’s conclusion (P > 0.05). As expected, serum levels of vitamin D were significantly higher in the intervention group compared to the placebo group at the trial's endpoint (P < 0.001). Conclusions: Vitamin D supplementation did not significantly affect vertigo and tinnitus in patients with Meniere’s disease. Further clinical trials with larger sample sizes and longer durations are recommended to confirm these findings.