Preparation and in Vitro Property Research of Cholic Acid Nanoparticles with Dual-functions of Hemostasis and Antibacterial
| Author | Jin Ma | en |
| Author | Cong Wang | en |
| Author | Tieying Yin | en |
| Author | Yang Jiang | en |
| Author | Wanjun Yu | en |
| Author | Xiaoyu Zhang | en |
| Author | Qin Qin | en |
| Author | Hua Yang | en |
| Author | Dechuan Zhang | en |
| Issued Date | 2023-12-31 | en |
| Abstract | Background: Hemorrhage control and anti-infection play a crucial role in promoting wound healing in trauma-related injuries. Objectives: This study aimed to prepare nanoparticles with dual functions of hemostasis and antibacterial properties. Methods: The dual-functional nanoparticles (CDCA-PLL NPs) were developed using a self-assembly method based on the electrostatic forces between poly-L-lysine (PLL) and Chenodeoxycholic acid (CDCA). The physicochemical properties, hemostatic properties, and antibacterial activities were investigated. Results: The prepared nanoparticles displayed a spherical structure, exhibiting a high drug loading capacity, encapsulation efficiency, and good stability. The CDCA-PLL NPs could reduce the hemolysis caused by PLL and promote the proliferation of human fibroblasts, indicating excellent biosafety. Moreover, CDCA-PLL NPs demonstrated a shorter in vivo hemostasis time and reduced blood loss in mouse tail vein hemorrhage, femoral vein hemorrhage, femoral artery hemorrhage, and liver hemorrhage models. Also, CDCA-PLL NPs showed excellent antibacterial efficacy against E. coli and S. aureus. Conclusions: CDCA-PLL NPs have great potential to be extensively applied as a hemostatic and antibacterial agent in various clinical conditions. | en |
| DOI | https://doi.org/10.5812/ijpr-135437 | en |
| Keyword | Poly-l-lysine | en |
| Keyword | Chenodeoxycholic Acid | en |
| Keyword | Hemostasis | en |
| Keyword | Antibacterial Effects | en |
| Publisher | Brieflands | en |
| Title | Preparation and in Vitro Property Research of Cholic Acid Nanoparticles with Dual-functions of Hemostasis and Antibacterial | en |
| Type | Research Article | en |