ACTH and Low Melanocortin-2 Receptor Expression Inhibit Infantile Spasm (IS) Seizures in Prenatal Stress (PS) Exposed Rats
| Author | Ying Zhang | en |
| Author | Shao-Yong Yuan | en |
| Author | Li-Ping Zou | en |
| Author | Ying-Xue Ding | en |
| Author | Bing He | en |
| Issued Date | 2017-08-31 | en |
| Abstract | Background: Infantile spasm (IS) is a catastrophic epileptic syndrome of childhood and is usually insensitive to conventional antiepileptic drugs. Studies revealed that prenatal stress (PS) exposure and Melanocortin-2 Receptor (MC2R) may be involved in the pathogenesis of IS. However, the exact mechanism still remains unknown. Methods: In this study, PS was initially given to Wistar rats and ACTH injection was performed in offsprings. Seizure was then induced and evaluated, followed by MC2R immunohistochemistry and expression detection. Results: Significant differences in seizure number, MC2R and CRH expressions were observed among different subgroups. Conclusions: Our study suggested that PS exposure may be an important factor in the pathogenesis of IS. ACTH together with low expression of MC2R, may inhibit IS seizures. | en |
| DOI | https://doi.org/10.5812/ijp.8081 | en |
| Keyword | ACTH | en |
| Keyword | Infantile Spasm | en |
| Keyword | MC2R | en |
| Keyword | Prenatal Stress Exposure | en |
| Publisher | Brieflands | en |
| Title | ACTH and Low Melanocortin-2 Receptor Expression Inhibit Infantile Spasm (IS) Seizures in Prenatal Stress (PS) Exposed Rats | en |
| Type | Research Article | en |