Hospitalization Outcomes and Mortality Predictors of SARS-Cov-2 Infection in the Elderly: A Single Center Experience from India
| Author | Viswanathan Pandurangan | en |
| Author | Sowmya Gopalan | en |
| Author | Sudha Madhavan | en |
| Author | Vaasanthi Rajendran | en |
| Author | Priyadarshini Varadaraj | en |
| Author | Lakshmi Marappa | en |
| Author | Aiswarya M Nair | en |
| Author | Rajkumar Mani | en |
| Author | Emmanuel Bhaskar | en |
| Orcid | Emmanuel Bhaskar [0000-0002-3524-641X] | en |
| Issued Date | 2021-04-30 | en |
| Abstract | Objectives: This study aimed to assess the outcome and mortality predictors of SARS-CoV-2 infection requiring hospitalization among elderly population. Methods: In this retrospective study, hospitalized elderly people with virologically confirmed SARS-CoV-2 infection were evaluated. Participants were divided into three groups of mild, moderate, and severe based on oxygenation. The primary outcome was death or discharge to home. Results: A total of 169 patients were studied (mean age: 68 years). Apart from respiratory symptoms, other reported symptoms included gastrointestinal complaints in 11% (n = 19), acute stroke in 1.1% (n = 2), delirium in 1.7% (n = 3), and anosmia or ageusia in 8.88% (n = 15). Also, 65 (38.5%) patients required oxygen support, 25 (14.7%) were admitted to the intensive care unit (ICU), 7 (4.1%) required non-invasive ventilation (Fio2 0.6 to 1.0), 14 (8.28%) were mechanically ventilated. 72 (42%) received steroid, and 100 (59%) received prophylactic heparin. Overall mortality was 12.4% (n = 21). Gender had no effect on mortality (P = 0.83). Presence of ≥ 3 risk factors, elevated neutrophil lymphocyte ratio, D-dimer, and lactate dehydrogenase, were associated with mortality (P = 0.001, P = 0.0005, P = 0.05, and P = 0.0005, respectively). Sepsis and cardiovascular events were higher among those who died. Conclusions: We observed a low mortality among the elderly treated with steroids compared to studies done in the pre-steroid period. Elevated NLR, LDH, and D-dimer were associated with mortality. | en |
| DOI | https://doi.org/10.5812/archcid.112397 | en |
| Keyword | Outcome | en |
| Keyword | Mortality | en |
| Keyword | Steroids | en |
| Keyword | Elderly | en |
| Keyword | LDH | en |
| Keyword | NLR | en |
| Keyword | SARS-Cov-2 | en |
| Publisher | Brieflands | en |
| Title | Hospitalization Outcomes and Mortality Predictors of SARS-Cov-2 Infection in the Elderly: A Single Center Experience from India | en |
| Type | Brief Report | en |
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