The effect of dopamine D2 receptors of the dorsal hippocampus on the Histamine-induced anxiety behavior in mice

Abstract

Background: High levels of histamine and dopamine are found in the hippocampus. Furthermore, interaction between histamine and dopaminergic D2 receptors has been demonstrated in the modulation of some behaviors. In the present study, interaction between histamine and dopaminergic D2 receptor in the dorsal hippocampus in the anxiety behavior has been investigated.