The Effect of Pentoxifylline on <i>bcl-2</i> Gene Expression Changes in Hippocampus after Long-term use of Ecstasy in Wistar Rats

Abstract

3,4- Methylenedioxymethamphetamine (MDMA or “Ecstasy”) is a psychoactive and hallucinogenic drug of abuse. MDMA has been shown to produce neurotoxicity both in animals and humans. Recently, the vasodilator drugs such as pentoxifylline is one of the new strategies which have been considered as neuroprotector. In this study effect of pentoxifylline on bcl- 2 gene expression changes in hippocampus of rat following long- term use of ecstasy was investigated.