Comparison of Serum Levels of Hormone Omentin-1 and Insulin Resistance Markers in Active-Obese, Inactive-Obese and Inactive Normal-Weight Men

Abstract

Background Omentin-1 is an adipokine, mainly produced by visceral adipose tissue that improves insulin resistance. Objective This study compared the serum levels of omentin-1 and insulin resistance markers in active-obese, inactive-obese and inactive normal-weight men. Methods In this cross-sectional study, 45 men (35.0±4.2 years, no symptoms of illness) were assigned to active-obese (n=16, Body Mass Index (BMI)=28-33.9 kg/m2 and 3-5 score in the Physical Activity level questionnaire (PA-R score), inactive-obese (n=18, BMI=28-33.9 kg/m2 and 1 in PA-R score) and inactive normal-weight (n=11, BMI=18.5-24.9 kg/m2 and 1 in PA-R score) groups. Blood samples were taken from all subjects in fasting state to measure the serum levels of omentin-1, insulin and glucose. Also, Homeostasis Model Assessment Index (HOMA-IR) for insulin resistance was assessed. Findings The results showed that the omentin-1 concentration was significantly lower in inactive normal-weight compared to the obese groups (P