Accessory Gene Regulator Specificity Groups Among Staphylococcus aureus Isolated From Hospitalized Children
| Author | Abdolmajid Ghasemian | en |
| Author | Shahin Najar Peerayeh | en |
| Author | Bita Bakhshi | en |
| Author | Mohsen Mirzaee | en |
| Issued Date | 2014-04-01 | en |
| Abstract | Background:: Staphylococcus aureus (S. aureus) especially those with methicillin resistance are human pathogens capable of causing a wide variety of diseases, ranging from mild skin lesions to systemic and fatal infections. Objectives:: The aim of this study was to detect the accessory gene regulator (agr) specificity groups among methicillin resistant and susceptible S. aureus isolated from children. Materials and Methods:: During July 2012 to January 2013, 22 S. aureusc linical isolates were collected from children aged between 2 to 11, in Loghman Hospital of Tehran. Antibiogram test was performed using disc diffusion method. Polymerase chain reaction (PCR) was conducted to detect mecA gene and agr specificity groups. Results:: Among 22 S. aureus clinical isolates collected from children, five isolates (22.7 %) were resistant to methicillin. fourteen isolates (63.6%) were resistant to amoxicillin and all were susceptible to vancomycin and linezolid. Agr specificity group I was detected in 12 (54.5%) isolates (in 2 MRSA and 10 MSSA isolates), agr group II in four (18%, in 3 MSSA and 1 MRSA), group III in 3 (9%, 2 in MSSA and one in MRSA), while agr specificity group IV was found in three (13.6%, 2 MSSA and 1 MRSA) isolates. Conclusions:: The agr specific group I had the highest rate of detection among pathogens isolated from hospitalized children in Tehran. | en |
| DOI | https://doi.org/10.5812/pedinfect.16096 | en |
| Keyword | <i>Staphylococcus aureus</i> | en |
| Keyword | Drug Resistance | en |
| Keyword | Microbial pathogenesis | en |
| Keyword | <i>mecA</i> gene | en |
| Publisher | Brieflands | en |
| Title | Accessory Gene Regulator Specificity Groups Among Staphylococcus aureus Isolated From Hospitalized Children | en |
| Type | Research Article | en |
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