Association Between Interleukin-19 (IL-19) and Interleukin-20 (IL-20) Genes Polymorphisms with Multiple Sclerosis in an Iranian Population
| Author | Tooba Nakhzari Khodakheir | en |
| Author | Alireza Pourtalebi-Firoozabadi | en |
| Author | Mohammad Hossein Sangtarash | en |
| Author | Abbas Nikravesh | en |
| Issued Date | 2017-04-30 | en |
| Abstract | Myelin-directed autoimmunity seems to be an important factor in the pathogenesis of multiple sclerosis (MS). Growing productions of both anti-inflammatory and pro-inflammatory cytokines are frequent findings in MS. The IL-10 is an immunosuppressive cytokine in the immune system. In the clinical trial, it is considered to be an anti-inflammatory therapy for inflammatory bowel disease and many other autoimmune diseases such as psoriasis, rheumatoid arthritis, and MS. IL-19 as well as IL-20 belong to the IL-10 family. It appears that polymorphisms, within these genes, affected the level of gene expression. The goal of the present study was investigating the possible associations between IL-19 and IL-20 genes polymorphisms with multiple sclerosis. Therefore, 100 MS patients and 100 healthy controls were recruited in this study. Genotyping for the IL-19 (rs2243158GC, rs2243168GC) and IL-20 1053TG (rs2981572, rs2981573) were executed using Tetra-primer ARMS-PCR. The GC and AT genotypes related to IL-19 polymorphisms, rs2243158 and rs2243168, respectively, were significantly associated with multiple sclerosis (P = 0.004 and P < 0.001 respectively). Moreover, in the polymorphisms of IL-20, TG genotype of rs2981572 and AG genotype of rs2981573 were significantly associated with the disease (P = 0.001 and P = 0.04 respectively). According to the results, these genotypes play a protective role against multiple sclerosis. | en |
| DOI | https://doi.org/10.5812/gct.11957 | en |
| URI | https://brieflands.com/journals/gct/articles/11957 | en |
| Keyword | IL-19 | en |
| Keyword | IL-20 | en |
| Keyword | Multiple Sclerosis | en |
| Keyword | Tetra ARMS-PCR | en |
| Keyword | Genotyping | en |
| Publisher | Brieflands | en |
| Title | Association Between Interleukin-19 (IL-19) and Interleukin-20 (IL-20) Genes Polymorphisms with Multiple Sclerosis in an Iranian Population | en |
| Type | Research Article | en |
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