Does Kidney Transplantation With Deceased or Living Donor Affect Graft Survival?
| Author | Eghlim Nemati | en |
| Author | Behzad Einollahi | en |
| Author | Mahboob Lesan Pezeshki | en |
| Author | Vahid Porfarziani | en |
| Author | Mohamad Reza Fattahi | en |
| Issued Date | 2014-07-01 | en |
| Abstract | Background: There are growing numbers of patients with end-stage renal disease globally at an unexpected rate. Today, the most serious challenge in transplantation is organ shortage; hence, using deceased donor is increasingly encouraged. Objectives: The aim of the study was to investigate the differences in survival rates between kidney transplant recipients with deceased donor and living donor. Patients and Methods: In a retrospective cohort study, 218 patients who had undergone kidney transplantation in our institute from April 2008 to September 2010 were recruited. Demographics and post-transplantation follow-up data including immunosuppression regimens, rejection episodes, and survival rates were evaluated. The patients were assigned to two groups according to the donor kidney transplantation: group I, living donor kidney transplants; and group II, deceased donor kidney transplants. Results: Although there were no significant differences in one-year survival rates of patient and graft between study groups, three-years survival rates of patient and graft were significantly longer in living donor kidney transplants in comparison with the deceased donor kidney recipients (P = 0.006 and P = 0.004, respectively). In Cox-regression model after adjusting for other confounding factors such as age, sex, diabetes mellitus, and first- or second-time transplantation, overall patient and graft survivals were also significantly shorter in deceased kidney transplantation than those who received kidney from a living donor (HR, 3.5; 95% CI, 1.2-10.4; and P = 0.02 for patient survival; and HR, 5.4; 95% CI, 1.5-19.5; and P = 0.009 for graft survival). Conclusions: We found acceptable short-term survival in both groups; however, living donor recipients continue to have better long-term patient and graft survival rates. | en |
| DOI | https://doi.org/10.5812/numonthly.12182 | en |
| Keyword | Living Donor | en |
| Keyword | Donor | en |
| Keyword | Survival | en |
| Keyword | Kidney Transplantations | en |
| Publisher | Brieflands | en |
| Title | Does Kidney Transplantation With Deceased or Living Donor Affect Graft Survival? | en |
| Type | Research Article | en |
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