The Effect of Oral Administration of L-Tyrosine, Folic acid and Pyridoxine on Perphenazine Induced Catatonia in Rat
| Author | Ardeshir Arzi | en |
| Author | Mohsen Rezaei | en |
| Issued Date | 2003-07-31 | en |
| Abstract | L-tyrosine, B6 and folic acid are involved in biosynthesis of DOPA and consequently dopamine. The aim of this study was to investigate the antiparkinsonian effect of these agents in perphenazine-induced catatonia in rats. Murprogo method or scored muscular rigidity, which is induced by a phenothiazine, was used to evaluate the antiparkinsonian effect of these agents. A significant decrease in muscular rigidity was observed in groups that received L-tyrosine. However, groups which had received vitamin(s) only showed no significant decrease in muscular rigidity as compared with the control group. On the other hand, the group receiving folic acid plus L-tyrosine showed a lower degree of muscular rigidity in comparison with the other groups. | en |
| DOI | https://doi.org/10.22037/ijpr.2010.42 | en |
| URI | https://brieflands.com/journals/ijpr/articles/127960 | en |
| Keyword | Rat | en |
| Keyword | Parkinson's disease | en |
| Keyword | Pyridoxine | en |
| Keyword | Folic acid | en |
| Keyword | L-tyrosine | en |
| Publisher | Brieflands | en |
| Title | The Effect of Oral Administration of L-Tyrosine, Folic acid and Pyridoxine on Perphenazine Induced Catatonia in Rat | en |
| Type | Research Article | en |
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