Microencapsulation of Probiotics by Calcium Alginate-gelatinized Starch with Chitosan Coating and Evaluation of Survival in Simulated Human Gastro-intestinal Condition

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AuthorMohammad Ali Khosravi Zanjanien
AuthorBabak Ghiassi Tarzien
AuthorAnousheh Sharifanen
AuthorNima Mohammadien
Issued Date2014-07-31en
AbstractMicroencapsulation as one of the most modern methods has considerable effects on probiotic survival. In this study Lactobacillus casei (ATCC 39392) and Bifidobacterium bifidum (ATCC 29521) were encapsulated using calcium alginate-gelatinized starch, chitosan coating and inulin via emulsion technique, and were incubated in simulated gastric juice (along with pepsin, pH=1.5) and simulated intestinal juice (along with pancreatin and bile salts, pH = 8) for 2 hours at 37 oC. The morphology and size of microcapsules were measured by scanning electron and optical microscopy. The results indicated that the survival of microencapsulated probiotic increased significantly in simulated gastro-intestinal condition (P < 0.05). Chitosan coating played a significant role in the protection of probiotic bacteria in simulated gastro-intestinal condition and the diameter of the microcapsules increased with the addition of chitosan coating. In general, this study indicated that microencapsulation with alginate-gelatinized starch coated with chitosan could successfully and significantly protect probiotic bacteria against adverse condition of simulated human gastro-intestinal condition.en
DOIhttps://doi.org/10.22037/ijpr.2014.1550en
KeywordMicroencapsulationen
KeywordCalcium alginate-gelatinized starchen
KeywordChitosanen
KeywordInulinen
KeywordSimulated gastro-intestinal conditionen
PublisherBrieflandsen
TitleMicroencapsulation of Probiotics by Calcium Alginate-gelatinized Starch with Chitosan Coating and Evaluation of Survival in Simulated Human Gastro-intestinal Conditionen
TypeOriginal Articleen

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Iranian Journal of Pharmaceutical Research