Risk Factors and Outcomes of Patients with <i>Pseudomonas aeruginosa </i>Bloodstream Infection in the Intensive Care Unit
| Author | Ozge Caydasi | en |
| Author | Eyüp Arslan | en |
| Author | Ayse Sababli Cetin | en |
| Author | Fatma Yılmaz Karadağ | en |
| Author | Asiye Tuncel Dede | en |
| Author | Esra Adiyeke | en |
| Author | Narin Gundogus | en |
| Author | Derya Ozturk Engin | en |
| Orcid | Ozge Caydasi [0000-0003-2804-3101] | en |
| Issued Date | 2024-08-31 | en |
| Abstract | Background: Bloodstream infections (BSIs) caused by Pseudomonas aeruginosa have high mortality rates and pose a significant threat to healthcare settings. Objectives: We aimed to investigate the clinical risk factors related to mortality and the development of P. aeruginosa with difficult-to-treat resistance (DTR-PA) BSI in the intensive care unit. Methods: This was a retrospective, single-center study that included patients with P. aeruginosa BSI who were hospitalized between 2020 and 2022. The risk factors affecting 30-day mortality and the development of DTR-PA were investigated using both univariate and multivariate analyses. Results: A total of 140 patients were analyzed. The mean age was (66 ± 17.5) years, and 48% of the patients were male. Previous meropenem use was an independent risk factor for DTR-PA BSI (odds ratio, 2.68; 95% CI, 1.24 to 5.80; P = 0.012). Multivariate analysis demonstrated that the requirement for inotropic support was an independent risk factor for 30-day mortality [hazard ratio, 2.50; 95% confidence interval (CI), 1.33 to 4.68; P = 0.004]. Conclusions: Prior meropenem use was an independent risk factor for DTR-PA development. Strict policies for Carbapenem use and infection control procedures are essential to combat infections caused by DTR-PA. | en |
| DOI | https://doi.org/10.5812/jjm-150331 | en |
| Keyword | <i>Pseudomonas aeruginosa</i> | en |
| Keyword | Difficult-to-Treat Resistance | en |
| Keyword | Mortality | en |
| Keyword | Carbapenem Exposure | en |
| Keyword | Risk Factors | en |
| Publisher | Brieflands | en |
| Title | Risk Factors and Outcomes of Patients with <i>Pseudomonas aeruginosa </i>Bloodstream Infection in the Intensive Care Unit | en |
| Type | Research Article | en |