Therapeutic effects of Curcumin on renal tissue damages induced by ischemia reperfusion in rat
| Author | houshang najafi | en |
| Author | Saeed Changizi Ashtiani | en |
| Author | seyeed Hamid Madani | en |
| Author | Sajad Fakhri | en |
| Author | Zeynab Mohamadi yarijani | en |
| Author | Mehdi Hazem | en |
| Issued Date | 2015-03-30 | en |
| Abstract | Introduction: Curcumin has anti-inflammatory and anti-oxidative properties, and the aim of this study was to investigate the therapeutic effects of Curcumin on tissue damages induced by renal ischemia/ reperfusion. Materials and Methods: In this research, male Wistar rats were studied in 9 groups which were include sham with 24h reperfusion period, ischemia followed by 24h reperfusion, ischemia/reperfusion-24h which received a single dose 10, 20, or 30 mg/kg (i.p), Curcumin 30 min after ischemia, sham with 72h reperfusion period, ischemia followed by 72h reperfusion, ischemia/reperfusion-72h which received a single dose 20 mg/kg (i.p), Curcumin and ischemia/reperfusion-72h which received three doses of Curcumin (20 mg/kg, i.p) every 24 hours. At the end of reperfusion period, the left kidney tissue were collected and after staining with hematoxylin-eosin, subjected to microscopic study. Results: Ischemia/reperfusion leads to increased Bowman's space size, tubular necrosis, vascular congestion and intra-tubular proteinaceous casts in kidney which Curcumin therapy could partially improve all of them. But its effect in groups with 72h reperfusion period and receiving 3 dose of Curcumin was significantly greater than those received single dose and 24h reperfusion in comparison with their own sham groups. Conclusion: The results of this study demonstrated that three successive doses of curcumin can be more effective than single-dose treatment on tissue damages resulting from renal ischemia/ reperfusion in rat | en |
| DOI | https://doi.org/ | en |
| Keyword | Curcumin | en |
| Keyword | Acute Kidney Injury | en |
| Keyword | Ischemia/Reperfusion | en |
| Keyword | Reperfusion Injury | en |
| Keyword | Rat | en |
| Keyword | کورکومین | en |
| Keyword | نارسایی حاد کلیوی | en |
| Keyword | ایسکمی | en |
| Keyword | خون رسانی مجدد | en |
| Keyword | آسیب ناشی از خونرسانی مجدد | en |
| Keyword | موش صحرایی | en |
| Publisher | Brieflands | en |
| Title | Therapeutic effects of Curcumin on renal tissue damages induced by ischemia reperfusion in rat | en |
| Type | Research Article | en |