Antibacterial Activity of Silver Nanoparticles Produced by Plantago Ovata Seed Extract Against Antibiotic Resistant Staphylococcus aureus

Abstract

Background: Silver nanoparticles can be applied to control infections. Objectives: The current study aimed to detect antibacterial activity of silver nanoparticles produced by Plantago ovata seed extract against antibiotic resistant Staphylococcus aureus. Patients and Methods: All the antibiotic resistant Staphylococcus aureus strains isolated from the patients with urinary tract infection admitted to the hospitals in Zabol (South-eastern Iran) from January 2011 to January 2012 were studied. Then, minimum inhibitory concentration (MIC) of the isolates against the prepared extract was evaluated by the microdulition method. Results: The silver nanoparticles revealed Gaussian distributions with the average diameter of 13 nm with some deviations, and results showed that the highest and the lowest MIC of P. ovata seed extract were 100 and 12.5 mg/mL, respectively. Conclusions: The current study results showed that silver nanoparticles produced by Plantago ovata seed extract had an antibacterial effect on Staphylococcus aureus which was resistant against cefixime, trimethoprim-sulfamethoxazole and penicillin.