Molecular Aspects of Hepatocellular Carcinoma Caused by Hepatitis C Virus
| Author | Ali Karami | en |
| Author | Seyed Moayed Alavian | en |
| Author | Ali Najafi | en |
| Author | Mohammad Javad Hosseini | en |
| Issued Date | 2006-12-31 | en |
| Abstract | The hepatitis C virus (HCV) is a small, enveloped, single-stranded positive sense RNA virus with a diameter of about 50 nm belonging to the Hepacivirus genus of the family Flaviviridae. The HCV genome is translated to produce a single protein of around 3011 amino acids. This "polyprotein" is then proteolytically processed by viral and cellular proteases to produce structural (core protein, envelope glycoproteins E1 and E2, ARFP/F protein, p7) and nonstructural (NS2-3 autoprotease, NS3-4A, NS4B, NS5A, NS5B) proteins. Hepatocellular carcinoma (HCC) is one of the most frequent malignant tumors worldwide, with increasing incidence. It is estimated that approximately 300-400 thousands of people in the IRAN and 4 million in the United States are persistently infected. It is important for tumor control to identify the factors that predispose patients to death. A large number of molecular factors have been shown to associate with the invasiveness of HCC, and have potential prognostic significance. | en |
| DOI | https://doi.org/ | en |
| Keyword | Hepatitis C Virus (HCV) | en |
| Keyword | Hepatocellular Carcinoma | en |
| Keyword | Genomic and Proteomics | en |
| Publisher | Brieflands | en |
| Title | Molecular Aspects of Hepatocellular Carcinoma Caused by Hepatitis C Virus | en |
| Type | Review Article | en |
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