A kinetic study on changes of mouse peripheral blood lymphocyte subsets after administration of T-2 toxin
| Author | Jafar Salimian | en |
| Author | Najmeh Poursasan | en |
| Author | Farid Aziz jalilian | en |
| Author | Parviz Kokhaie | en |
| Author | Sona Dalilan | en |
| Issued Date | 2015-03-30 | en |
| Abstract | Introduction: T-2 mycotoxin, makes contamination in food and feed and causes poisoning in human and livestock. T-2 toxin induces serious effect on immune system cells. In this study, kinetic of blood peripheral lymphocyte subsets after T-2 toxin exposure was investigated. Materials and Methods: In this experimental study, sublethal dose of T-2 toxin was determined and then injected into male mice. 12, 24, 48 and 72 h after toxin injection, a boold sample was taken from experimental anaimals. Afterward, kinetics of lymphocyte subpopulations such as CD19+, CD3+, CD4+ and CD8+ cells were analyzed using flow cytometry. Results: Sublethal dose of T-2 toxin was determined as 2 mg/kg. After sublethal dose injection CD19+ B cell significantly was decreased at 12 h and was returned to normal range at 3th day post-injection. CD3+ and CD4+ T populations increased at 24 h and were returned to normal range at 48 h, but inversely CD8+ T cells was decreased at 12 h and returned to to normal limit at 48 h. Conclusion: Alteration on blood lymphocytes due to T-2 toxin was occurred in 12 to 24 h post-injection. CD19+ and CD8+ lymphocytes were sensitive cells to toxin effect. CD3+ and CD4+ populations were increased. This may be due to pro-inflammatory cytokine release.T-2 toxin has different effects on kinetic of peripheral blood lymphocyte populations. | en |
| DOI | https://doi.org/ | en |
| Keyword | Flow cytometry | en |
| Keyword | Kinetics | en |
| Keyword | Lymphocyte subsets | en |
| Keyword | T-2 toxin | en |
| Keyword | زیر جمعیتهای لنفوسیتی | en |
| Keyword | سم T-2 | en |
| Keyword | سینتیک | en |
| Keyword | فلوسایتومتر | en |
| Publisher | Brieflands | en |
| Title | A kinetic study on changes of mouse peripheral blood lymphocyte subsets after administration of T-2 toxin | en |
| Type | Research Article | en |