Interferon-Gamma and Interlukin-4 Patterns in BALB/c Mice Suffering From Cutaneous Leishmaniasis Treated With Cantharidin
| Author | Yahya Maroufi | en |
| Author | Fatemeh Ghaffarifar | en |
| Author | Abdolhosein Dalimi | en |
| Author | Zohreh Sharifi | en |
| Orcid | Fatemeh Ghaffarifar [0000-0003-0891-8214] | en |
| Issued Date | 2014-06-01 | en |
| Abstract | Background: Cutaneous leishmaniasis is a health problem in the world. Lesions should be treated on cosmetically or functionally important sites, such as the face and hands. Cantharidin is a terpenoid compound produced naturally by beetles of Meloidae and Oedemeridae families. Objectives: The current study aimed to investigate the effect of cantharidin on Cutaneous Leishmaniasis (CL) lesions and IFN-ϒ and IL-4 patterns in infected BALB/c mice. Materials and Methods: Infected BALB/c mice were divided into five groups as: untreated (control group), eucerin-treated and 0.05%, 0.1% and 0.5% cantharidin-treated. Lesions diameter was measured by Vernier caliper every three days for four weeks. Cytokines levels were measured by enzyme-linked immunosorbent assay (ELISA) using U-CyTech kit. Results: The results indicated that treatment with cantharidin exacerbates lesions compared with the controls, except for 0.05% cantharidin dose that restrained lesion growth significantly. Interferon gamma level in cantharidin-treated groups was significantly less than that of the control group. But interlukin-4 level was similar among the groups. Conclusions: The current study results indicated that high doses of cantharidin exacerbates leishmaniasis lesion, but low dose of cantharidin inhibits lesion growth. | en |
| DOI | https://doi.org/10.5812/jjm.10907 | en |
| Keyword | Mice | en |
| Keyword | Inbred BALB/c | en |
| Keyword | Cantharidin | en |
| Keyword | Leishmaniasis | en |
| Keyword | Cutaneous | en |
| Keyword | Interferon-gamma | en |
| Publisher | Brieflands | en |
| Title | Interferon-Gamma and Interlukin-4 Patterns in BALB/c Mice Suffering From Cutaneous Leishmaniasis Treated With Cantharidin | en |
| Type | Research Article | en |
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