Assessment of the Cytotoxic Effect of a Series of 1,4-Dihydropyridine Derivatives Against Human Cancer Cells
| Author | Nima Razzaghi-Asl | en |
| Author | Ramin Miri | en |
| Author | Omidreza Firuzi | en |
| Issued Date | 2016-07-31 | en |
| Abstract | Cancer is a leading cause of death worldwide. Despite the availability of several chemotherapeutic drugs, there is still a great need for more efficient agents for a better management of cancer. In this contribution, a series of 11 1,4-dihydropyridines (1,4-DHPs) (4a, 4b and 7a-i) were synthesized and evaluated for their cytotoxic effect against MCF-7, LS180 and MOLT-4 cancer cell lines using MTT assay. Synthesized 2,6-dimethyl-3,5-bis-N-(aryl/heteroaryl) carbamoyl-4-aryl-1,4-dihydropyridines exhibited different potencies ranging from weak to good cytotoxic activities, while no activity could be recorded for 1,4-bis(2,6-dimethyl-3,5-dialkyloxylcarbonyl,4-dihydropyridine-4-yl) benzene compounds (4a and 4b). Tested DHP derivatives were more potent against MOLT-4 cells, when compared to LS180 and MCF-7 cells. Compounds 7d (IC50 = 28.5 ± 3.5 µM), 7a (IC50 = 29.7 ± 4.7 µM) and 7a (IC50 = 17.4 ± 2.0 µM) were the most potent derivatives against MCF-7, LS180 and MOLT-4 cells, respectively. It appeared that the introduction of N-thiazolyl carbamoyl group at the C3 and C5 positions of DHP ring enhanced the cytotoxic potential of these derivatives (compounds 7a-e). The findings of this study suggest that some of the thiazole substituted 1,4-DHPs may be candidates for further modifications towards the discovery of potent anticancer agents. | en |
| DOI | https://doi.org/10.22037/ijpr.2016.1870 | en |
| Keyword | Synthesis | en |
| Keyword | Dihydropyridine | en |
| Keyword | Anticancer activity | en |
| Keyword | MTT assay | en |
| Publisher | Brieflands | en |
| Title | Assessment of the Cytotoxic Effect of a Series of 1,4-Dihydropyridine Derivatives Against Human Cancer Cells | en |
| Type | Original Article | en |
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