Evaluation of Suppressor of Cytokine Signaling 1, Interleukin-29 and Lysosomal Trafficking Regulator in Severe COVID-19
| Author | Mojdeh Lashkari | en |
| Author | Ashraf Kariminik | en |
| Author | Mohammad Javad Soltani-Banavandi | en |
| Orcid | Mojdeh Lashkari [0009-0008-0162-2211] | en |
| Orcid | Ashraf Kariminik [0000-0001-6489-9500] | en |
| Orcid | Mohammad Javad Soltani-Banavandi [0000-0001-7709-3354] | en |
| Issued Date | 2024-12-31 | en |
| Abstract | Background: The pathogenesis of Severe SARS-CoV-2 is closely linked to severe immune responses and inflammation caused by the SARS-CoV-2 virus. In this context, the suppressor of cytokine signaling 1 (SOCS1) has a crucial role in inhibiting cytokine-induced immune responses. On the other hand, interleukin-29 (IL-29) and lysosomal trafficking regulator (LYST) are important molecules involved in inducing immune responses. Objectives: This study aimed to assess the mRNA levels of SOCS1, IL-29, and LYST in the SARS-CoV-2-infected patients with severe symptoms. Methods: In this cross-sectional study, 70 SARS-CoV-2 infected patients with severe symptoms and 70 healthy controls were evaluated. RNA was extracted from peripheral blood and after cDNA synthesis, the mRNA levels of SOCS1, IL-29, and LYST were assessed by Real-Time PCR technique Results: The study revealed that severe COVID-19 patients exhibited a significant increase in mRNA levels of IL-29 compared to healthy individuals. However, there were no observed alterations in the mRNA levels of SOCS1 and LYST in the patient group. Conclusions: The results emphasize the importance of IL-29 as a potential biomarker or therapeutic target for severe COVID-19 cases. Further research is needed to investigate the specific mechanisms through which IL-29 influences immune responses and contributes to the development of severe disease. Additionally, exploring other factors that may regulate SOCS1 and LYST expression could provide a more comprehensive understanding of their roles in COVID-19 pathogenesis. | en |
| DOI | https://doi.org/10.5812/jkums-145333 | en |
| Keyword | SARS-CoV-2 | en |
| Keyword | SOCS1 | en |
| Keyword | IL-29 | en |
| Keyword | LYST | en |
| Keyword | COVID-19 | en |
| Keyword | Immune System | en |
| Publisher | Brieflands | en |
| Title | Evaluation of Suppressor of Cytokine Signaling 1, Interleukin-29 and Lysosomal Trafficking Regulator in Severe COVID-19 | en |
| Type | Research Article | en |
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