Application of the Chinese Visceral Adiposity Index in the Diagnosis of Hepatic Steatosis and Liver Fibrosis: A Cross-Sectional Study
| Author | Ayoub Basham | en |
| Author | Shideh Rafati | en |
| Author | Saeed Hosseini Teshnizi | en |
| Author | Ebrahim Evazi | en |
| Author | Fereshteh Khozeimeh | en |
| Author | Seyed Moayed Alavian | en |
| Author | Farkhondeh Razmpour | en |
| Orcid | Ayoub Basham [0000-0001-9049-2675] | en |
| Orcid | Shideh Rafati [0000-0003-3461-0555] | en |
| Orcid | Saeed Hosseini Teshnizi [0000-0002-5575-6855] | en |
| Orcid | Ebrahim Evazi [0009-0003-5593-8506] | en |
| Orcid | Seyed Moayed Alavian [0000-0002-4443-6602] | en |
| Orcid | Farkhondeh Razmpour [0000-0001-6258-4759] | en |
| Issued Date | 2023-12-31 | en |
| Abstract | Background: Visceral fat exerts a significant impact on the histopathology of metabolic dysfunction-associated steatotic liver disease (MASLD). Hence, we evaluated the application of the Chinese Visceral Adiposity Index (CVAI), a novel visceral fat marker, in predicting and diagnosing hepatic steatosis and liver fibrosis. Methods: After excluding individuals with liver disease or significant alcohol consumption, a total of 273 patients (57.9% males) aged over 18 were eligible for this cross-sectional study. Chinese Visceral Adiposity Index was calculated by age, Body Mass Index (BMI), waist circumference (WC), triglyceride, and high-density lipoprotein cholesterol (HDL-C). Hepatic steatosis and fibrosis were measured by elastography. A P-value of less than 0.05 was considered significant. Results: After adjusting for age, gender, metabolic diseases, and visceral obesity indices, each unit increase in CVAI elevated the odds of hepatic steatosis and liver fibrosis by 3.3% (P = 0.002) and 2.9% (P = 0.001), respectively. According to the analysis of variance (ANOVA), the grades of liver steatosis had a great impact on CVAI (P < 0.001), and CVAI well-discriminated grades of liver steatosis. Furthermore, the stages of liver fibrosis greatly impacted CVAI (P < 0.001), but it cannot distinguish the stages of liver fibrosis. The Area Under the Receiver Operating Characteristic Curve (AUROC) for S ≥ S1 was 0.800 (0.747 to 0.846), and for F ≥ F2 was 0.810 (0.759 to 0.855). Conclusions: We concluded that CVAI is a strong predictor and accurate diagnostic factor for liver steatosis and significant fibrosis; thus, it could be a tool for screening individuals at risk of liver steatosis and the irreversible complications of fibrosis. | en |
| DOI | https://doi.org/10.5812/hepatmon-150455 | en |
| URI | https://brieflands.com/journals/hepatmon/articles/150455 | en |
| Keyword | Metabolic Dysfunction-Associated Steatotic Liver Disease | en |
| Keyword | MASLD | en |
| Keyword | Non-alcoholic Fatty Liver Disease | en |
| Keyword | NAFLD | en |
| Keyword | Lipid Accumulation Product | en |
| Keyword | Visceral Adiposity Index | en |
| Publisher | Brieflands | en |
| Title | Application of the Chinese Visceral Adiposity Index in the Diagnosis of Hepatic Steatosis and Liver Fibrosis: A Cross-Sectional Study | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- hepatmon-23-1-150455-publish-pdf.pdf
- Size:
- 488.38 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF