Anti-proliferative effects of new synthesized hydrazone derivatives on breast, colon and hepatic cancer cells
| Author | Mehrasa Shademani | en |
| Author | Nasrin Nassiri Koopaei | en |
| Author | Nasrin Shirzad Yazdi | en |
| Author | Homa Azizian | en |
| Author | Zahra Mousavi | en |
| Author | Mona Salimi | en |
| Author | Ali Almasirad | en |
| Issued Date | 2018-12-31 | en |
| Abstract | Introduction: Despite the advances made in research on cancer, there is still no effective way to treat this condition. A number of compounds including hydrazone derivatives have been increasingly investigated as anticancer agents. So, in this study a series of novel hydrazone derivatives were designed and synthesized as potential anticancer compounds and their cytotoxic effects were further evaluated. Materials and Methods: The designed hydrazone compounds (1-9) were synthesized in three steps and their structures were characterized by different instrumental analysis methods. The cytotoxic activity was measured using MTT assay at 48 and 72 h on human breast, colon and liver cancer cell lines. Results: The obtained percentage of cytotoxicity indicated that some compounds were potent against cancer cell lines and the most effective incubation time was after 72 h of treeatment. Among the synthesized compounds, compounds 3 and 6 revealed the considerable cytotoxic activity on breast, liver and colon cells after 72 h of treatment ranging from 60 to 80%. Conclusion: The results obtained in this section can be used as the starting point for the development of new cancer chemotherapy agents | en |
| DOI | https://doi.org/ | en |
| Keyword | Cytotoxic | en |
| Keyword | Chemotherapy | en |
| Keyword | Hydrazones | en |
| Keyword | Carcinoma Cell Line | en |
| Keyword | Neoplasms | en |
| Keyword | سمیت سلولی | en |
| Keyword | شیمی درمانی | en |
| Keyword | هیدرازون ها | en |
| Keyword | رده سلولی سرطانی | en |
| Keyword | سرطانها | en |
| Publisher | Brieflands | en |
| Title | Anti-proliferative effects of new synthesized hydrazone derivatives on breast, colon and hepatic cancer cells | en |
| Type | Research Article | en |
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