HFE Mutations C282Y and H63D in Iranian Population With Type 2 Diabetes
| Author | Neda Golchin | en |
| Author | Hajie Bibi Shahbazian | en |
| Author | Heshmatollah Shahbazian | en |
| Author | Alireza Zare Bidoki | en |
| Author | Javad Mohammadi Asl | en |
| Issued Date | 2015-04-01 | en |
| Abstract | Background: Type 2 diabetes (T2D) is a common metabolic disease caused by insulin secretion defects, which is associated with a variety of complications such as retinopathy, nephropathy, and neuropathy. Objectives: Regarding the relationship between type 2 diabetes and hereditary chromatists, we conducted a genetic analysis on two previously reported mutations C282Y and H63D related to the HFE gene in our population. Patients and Methods: Altogether, 145 patients with type 2 diabetes and 145 healthy controls were examined. A genotyping assay performed using electrophoresis of the DNA digestion products from MboI and RsaI for H63D and C282Y, respectively. Results: Results showed a significant difference between case and controls regarding C282Y (P value < 0.001) and H63D genotypes (P value = 0.013). We also found a relationship between both mutations and nephropathy. Moreover, the difference between C282Y genotypes of patients with retinopathy and healthy controls were statistically significant (P value = 0.020) while there was no association between H63D and retinopathy. In addition, observed differences of both mutations were significant when nephropathic patients compared to the controls. Conclusions: Our study showed a significant association between H63D and C282Y mutations and the risk of type 2 diabetes in Iranian population. | en |
| DOI | https://doi.org/10.5812/jjhr.6(2)2015.24659 | en |
| URI | https://brieflands.com/journals/jjcmb/articles/21839 | en |
| Keyword | Mutation | en |
| Keyword | Type 2 Diabetes Mellitus | en |
| Keyword | Insulin | en |
| Publisher | Brieflands | en |
| Title | HFE Mutations C282Y and H63D in Iranian Population With Type 2 Diabetes | en |
| Type | Research Article | en |
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