Neuroprotective Effect of Total and Sequential Extract of <i>Scrophularia striata Boiss</i>. in Rat Cerebellar Granule Neurons Following Glutamate- Induced Neurotoxicity: An <i>In-vitro </i>Study

Abstract

Neuroprotective effect of the extract from aerial parts of Scrophularia striata Boiss (Scrophulariaceae) was investigated against glutamate-induced neurotoxicity on cultured rat pups Cerebellar Granule Neurons (CGNs). CGNs from 8 days old Sprague-Dawley rat were prepared and cultured. The experiments were performed after 8 days in culture. The plant was collected from the northeastern part (Ruin region) of Iran and air-dried at room temperature. The total extract was prepared with maceration of prepared powder in ethanol 80% for three times.