Lifestyle Intervention and Vitamin E Therapy in Obese Children with Nonalcoholic Fatty Liver Disease
| Author | Robabeh Ghergherehchi | en |
| Author | Nazanin Hazhir | en |
| Author | Manizheh Mostafa Gharehbaghi | en |
| Issued Date | 2012-10-25 | en |
| Abstract | Background: Nonalcoholic fatty liver disease (NAFLD) is a very common chronic disorder and obesity is thought to be the most common etiology of fatty infiltration of the liver. Objectives: The objective of this study is to compare the effect of lifestyle intervention alone or in combination with vitamin E therapy in obese pediatric nonalcoholic fatty liver disease (NAFLD). Patients and Methods: In the double-blind placebo study, 33 obese children with NAFLD from 2008 to 2009 were included. Lifestyle intervention (balanced calorie diet, 1300-1800 kcal/d and physical activity) was prescribed to all. The patients were concurrently randomized to receive vitamin E 400 mg/d (n = 17)] or placebo (n = 16). Results: At the end of six months of therapy there was significant change in body mass index, serum aminotransferases, triglycerides, total cholesterol and low density lipoprotein-cholesterol levels in both groups (P Conclusions: lifestyle intervention with diet and physical exercise in obese children with NAFLD were induced weight loss and was associated with a significant improvement in liver function. Vitamin E did not seem to increase the efficacy of lifestyle intervention. | en |
| DOI | https://doi.org/10.17795/compreped-6249 | en |
| Keyword | Children | en |
| Keyword | Lifestyle | en |
| Keyword | Fatty Liver | en |
| Keyword | Liver Diseases | en |
| Keyword | Obesity | en |
| Keyword | Vitamin E | en |
| Publisher | Brieflands | en |
| Title | Lifestyle Intervention and Vitamin E Therapy in Obese Children with Nonalcoholic Fatty Liver Disease | en |
| Type | Research Article | en |
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