Effects of Purified Omega-3 Fatty Acids on Serum Lipoproteins and Malondialdehyde in Postmenopausal Fat Women Receiving Hormone Replacement Therapy
| Author | Shidfar F | en |
| Author | Keshavarz A | en |
| Author | Jalali M | en |
| Author | Miri R | en |
| Author | Amri A | en |
| Author | Shidfar SH | en |
| Issued Date | 2004-09-01 | en |
| Abstract | Introduction: Regular intake of n-3 fatty acids of marine origin have desirable effects on serum lipoproteins and reduce coronary vascular disease (CVD). n-3 fatty acid supplementation decreased serum triglyceride concentrations in studies in which most of the subjects were male. The effects of n-3 fatty acids supplementation in fat women especially postmenopausal fat women have received little attention. The aim of this study was to determine whether purified n-3 fatty acids have desirable effects on serum lipoproteins, malondialdehyde (MDA) and lipoprotein risk factors for CVD in postmenopausal fat women receiving hormone replacement therapy (HRT). Materials and Methods: In a double-blind, placebo-controlled trial of parallel design, 35 postmenopausal women receiving hormone replacement therapy were randomly allocated to receive 2 g purified n-3 fatty acids or placebo for 10 weeks. Serum lipoproteins and MDA were determined on days 0 and 70. Results: Serum levels of triglycerides (TG) decreased significantly in the n-3 fatty acids group at the end of study compared to the initial values, and also compared to control group (26%, p< 0.003 and 29%, p< 0.01, respectively)_In the n-3 fatty acids group, serum levels of TG/HDL-C decreased significantly at the end of the study compared to initial values and, at the end of the study, compared to control group as well (23 %, P Conclusion: Supplementation with purified n-3 fatty acids can favorably influence selected CHD risk factors, particulary by achieving marked reduction in serum TG and TG/HDL-C levels in postmenopausal fat women receiving HRT. | en |
| DOI | https://doi.org/ | en |
| Keyword | n-3 fatty acids | en |
| Keyword | Triglycerides | en |
| Keyword | Postmenopausal women | en |
| Keyword | HDL-C | en |
| Keyword | Malondialdehyde | en |
| Publisher | Brieflands | en |
| Title | Effects of Purified Omega-3 Fatty Acids on Serum Lipoproteins and Malondialdehyde in Postmenopausal Fat Women Receiving Hormone Replacement Therapy | en |
| Type | Research Article | en |