Effect of Rilmenidine on Substantia Nigra Neurons Injury in a Rat Model of Parkinson's Disease
| Author | Hadi Keshavarzi | en |
| Author | Shahram Darabi | en |
| Author | Zahra Zia | en |
| Author | Fatemeh Sabbaghziarani | en |
| Issued Date | 2023-12-31 | en |
| Abstract | Background: Parkinson's disease (PD) is a rapidly progressive neurodegenerative disease characterized by the gradual loss of dopaminergic (DA) neurons in the substantia nigra (SNpc) and reduced DA innervation in the striatum. Objectives: This study aimed to investigate the impact of rilmenidine on DA neurons in the SNpc using a rat model of PD induced by 6-hydroxydopamine. Methods: A total of thirty Wistar rats were randomly assigned to three groups: Sham, lesion, and treatment. In each group, a behavioral evaluation utilizing apomorphine was conducted one week prior to surgery and repeated four weeks after the procedure. In the treatment group, 10 mg/kg rilmenidine was injected intraperitoneally four times a week after surgery. Microscopic examination of the SNpc was performed after the preparation of brain tissue blocks, Nissl staining, photography of slides, and counting of neurons. The number of rotations and neurons in the SNpc were analyzed after surgery using ANOVA and Tukey’s test. The number of rotations before and after surgery and the number of cells in the right and left hemisphere were compared using the paired t-test. The significance level was set at P ≤ 0.05. Results: The number of rotations significantly decreased, and the number of neurons in the SNpc significantly increased in the treatment group compared to the lesion group (P ≤ 0.001). Conclusions: Rilmenidine can reduce the neuronal damage induced by 6-hydroxydopamine in the SNpc. | en |
| DOI | https://doi.org/10.69107/jid-150909 | en |
| Keyword | Parkinson's Disease | en |
| Keyword | Rilmenidine | en |
| Keyword | Autophagy | en |
| Keyword | Substantia Nigra | en |
| Keyword | 6-Hydroxydopamine | en |
| Publisher | Brieflands | en |
| Title | Effect of Rilmenidine on Substantia Nigra Neurons Injury in a Rat Model of Parkinson's Disease | en |
| Type | Research Article | en |
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