Association Between HLA-B Polymorphisms and Autism Spectrum Disorder in Chinese Population
| Author | Guojun Kang | en |
| Author | Qi Kang | en |
| Author | Xiaojing Zhu | en |
| Author | Rixin Li | en |
| Author | Shangchao Zhang | en |
| Author | Yaoyao Sun | en |
| Author | MIngyuan Zhang | en |
| Author | Xin Chen | en |
| Author | Yueying Wang | en |
| Author | Huiyi Jiang | en |
| Author | Yaqin Yu | en |
| Author | Qiong Yu | en |
| Orcid | Qiong Yu [0000-0003-1143-1749] | en |
| Issued Date | 2020-02-10 | en |
| Abstract | Objectives: The aim of this study was to investigate the association between 2 single-nucleotide polymorphisms (SNP) of HLA-B and autism spectrum disorder (ASD). Methods: We enrolled 84 ASD and 182 healthy children in case-control study, and 67 family trios in family-based study. Two tag SNPs (rs1058026, rs2770) in gene HLA-B were selected to determine the association with ASD. Chi-square test was used in case-control study, haplotype relative risk test (HRR) and transmission disequilibrium test (TDT) analysis were performed in family-based study. Results: SNP rs1058026 was found significantly associated with ASD in family-based study (P = 0.016 for HRR; P = 0.020 for TDT), but not in case-control study. Conversely, SNP rs2770 did not show association with ASD in both studies. Conclusions: The association observed from this study indicates that gene HLA-B might play a role in ASD in Chinese population. | en |
| DOI | https://doi.org/10.5812/ijp.90110 | en |
| Keyword | Autism Spectrum Disorder | en |
| Keyword | Single-Nucleotide Polymorphisms | en |
| Keyword | Human Leukocyte Antigen | en |
| Keyword | HLA-B | en |
| Publisher | Brieflands | en |
| Title | Association Between HLA-B Polymorphisms and Autism Spectrum Disorder in Chinese Population | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- ijp-30-1-90110.pdf
- Size:
- 128.52 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF