Optimization of <i>In</i><i>-</i><i>vitro </i>Permeation Pattern of Ketorolac Tromethamine Transdermal Patches
| Author | Pintu Kumar De | en |
| Author | Subrata Mallick | en |
| Author | Biswajit Mukherjee | en |
| Author | Sagar Sengupta | en |
| Author | Satyanarayan Pattnaik | en |
| Author | Subrata Chakraborty | en |
| Issued Date | 2011-04-30 | en |
| Abstract | The present study was undertaken to develop a suitable transdermal matrix patch of ketorolac tromethamine with different proportions of polyvinyl pyrrolidone (PVP) and ethyl cellulose (EC) using a D-optimal mixture design. The prepared transdermal patches were subjected to different physicochemical evaluation. The surfacet opography of the patches was examined by scanning electron microscopy (SEM). The drug-polymer interaction studies were performed using Fourier transform infrared spectroscopic (FTIR) technique. A correlation between in-vitro drug-release and in-vitro skin permeation was established and the criterion of desirability was employed to optimize the formulation. The results of the physicochemical characterization and in-vitro permeation of the prepared patches were promising to formulate transdermal patches with PVP/EC combinations. | en |
| DOI | https://doi.org/10.22037/ijpr.2011.927 | en |
| Keyword | Ketorolac | en |
| Keyword | Transdermal | en |
| Keyword | Optimization | en |
| Keyword | SEM | en |
| Keyword | FTIR | en |
| Publisher | Brieflands | en |
| Title | Optimization of <i>In</i><i>-</i><i>vitro </i>Permeation Pattern of Ketorolac Tromethamine Transdermal Patches | en |
| Type | Original Article | en |
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