The Analgesic and Anti-inflammatory Effects of Partially Purified Polysaccharide Fractions of Cell-free Medium and Biomass of <i>Spirulina platensis</i> PCST5
| Author | Mohammad Dehghanizadeh Baghdadabad | en |
| Author | Nima Naderi | en |
| Author | Vahideh Atabaki | en |
| Author | Mohammad Ali Faramarzi | en |
| Author | Maryam Tabarzad | en |
| Author | Tahereh Hosseinabadi | en |
| Orcid | Nima Naderi [0000-0003-4591-8918] | en |
| Orcid | Vahideh Atabaki [0000-0003-0292-0487] | en |
| Orcid | Mohammad Ali Faramarzi [0000-0002-8822-453X] | en |
| Orcid | Maryam Tabarzad [0000-0001-9923-0639] | en |
| Orcid | Tahereh Hosseinabadi [0000-0003-3127-0233] | en |
| Issued Date | 2023-12-31 | en |
| Abstract | Background: Spirulina is a cyanobacteria species containing various bioactive compounds. Spirulina is a known source of nutrients in some traditional diets. Different activities have been reported for various extracts of S. platensis. Objectives: In this study, the polysaccharide content of culture media and biomass extract of one species of Spirulina was partially purified, and its analgesic and anti-inflammatory effects were evaluated. Methods: Spirulina platensis PCST5 was cultured in a sterile Zarouk medium at 27°C and 16/8h of light/ dark exposure cycle for 25 days. Then, the polysaccharide content of biomass and cell-free culture medium samples (BPSs and CFPSs, respectively) was partially purified. The analgesic and anti-inflammatory effects were evaluated using animal models. Results: 16S rRNA gene analysis confirmed that the organism was genetically similar to Spirulina platensis. The CFPSs (30 and 100 mg/kg) and BPSs (30 mg/kg) significantly reduced pain-related behaviors in rats. Similarly, all samples could significantly reduce carrageenan-induced paw inflammation volume compared with the control group. Our results suggest Spirulina's polysaccharide fractions (CFPSs and BPSs) had significant analgesic and anti-inflammatory effects. Conclusions: Since Spirulina is a readily available source of bioactive compounds, finding such potent anti-inflammatory and anti-nociceptive compounds can provide promising leads for novel drug development. | en |
| DOI | https://doi.org/10.5812/ijpr-136661 | en |
| Keyword | Cyanobacteria | en |
| Keyword | Pain | en |
| Keyword | Inflammation | en |
| Keyword | Formaldehyde | en |
| Keyword | Carrageenan | en |
| Keyword | Polysaccharide | en |
| Publisher | Brieflands | en |
| Title | The Analgesic and Anti-inflammatory Effects of Partially Purified Polysaccharide Fractions of Cell-free Medium and Biomass of <i>Spirulina platensis</i> PCST5 | en |
| Type | Research Article | en |