Association Between A561C Polymorphism of E-Selectin Gene and Coronary Arterial Disease in Southeastern Iranian Population

Abstract

Background: Numerous factors including genetic factors play a role in pathogenesis of coronary atherosclerosis. It has been reported that polymorphisms of genes encoding adhesion molecules are associated with atherosclerosis. Objectives: The present research aimed to evaluate A561C polymorphism of the E-selectin gene in patients with coronary arterial diseases (CAD). Materials and Methods: Eighty seven CAD patients and 93 age- and sex-matched control subjects were enrolled in this research. The polymorphism of A561C in the E-selectin gene was defined by polymerase chain reaction followed by restriction fragment length polymorphism (PCR-RFLP). Results: The prevalence’s of AA, AC and CC genotypes were 55.2%, 24.1% and 20.7% in CAD patients and 51.6%, 40.9% and 7.5% in the control subjects, respectively. The frequencies of the C allele were significantly higher in CAD patients compared with control groups (P < 0.05). Logistic regression analysis revealed a significant association between the C allele and the risk of CAD (OR = 1.61, 95%CI = 1.03-2.51). Conclusions: Our results displayed that presence of C allele at position 561 E-selection gene is associated with increased risk of atherosclerosis disease in the southeastern Iranian population. This polymorphism may be able to affect leukocyte-endothelial interactions, which may account for the pathogenesis of atherosclerosis.