Synergistic Effect of ZnO Nanoparticles and Carbon Nanotube and Polymeric Film on Electrochemical Oxidation of Acyclovir

AuthorGhasem Karim-Nezhaden
AuthorArezu Sarkaryen
AuthorZeynab Khorablouen
AuthorParisa Seyed Dorrajien
Issued Date2018-01-31en
AbstractA simple and selective carbon paste electrode has been developed for the electrochemical determination of acyclovir (ACV). This electrode was designed by incorporation of multi-walled carbon nanotubes (MWCNTs) and ZnO nanoparticles into the carbon paste matrix, and then poly (o-aminophenol; OAP) film were subsequently electropolymerized on it. The surface structure of nanoparticles were characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Surface morphology and electrochemical properties of the prepared nanocomposite modified electrode were investigated by SEM and cyclic voltammetry (CV). The calibration graph was linear over the concentration range 0.089 to 7.96 µg mL-1 for ACV determination with a detection limit of 0.067 µg mL-1. The proposed electrode was successfully applied for ACV determination in pharmaceutical formulations with satisfactory results.en
DOIhttps://doi.org/10.22037/ijpr.2018.2171en
KeywordAcycloviren
KeywordMulti-walled carbon nanotubesen
KeywordZnO nanoparticlesen
Keyword<i>O</i>-aminophenolen
KeywordCarbon paste electrodeen
PublisherBrieflandsen
TitleSynergistic Effect of ZnO Nanoparticles and Carbon Nanotube and Polymeric Film on Electrochemical Oxidation of Acycloviren
TypeOriginal Articleen

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