Ulcerative Colitis Remission after Renal Transplantation: Two Case Reports

Abstract

The combination of ulcerative colitis (UC) and end stage renal disease (ESRD) is uncommon. Immunosuppressive drugs that are used after kidney transplantation are considered as effective therapeutic alternatives for UC. We report two renal transplant recipients with long term refractory UC prior to kidney transplantation and confirmed by histological examination, cured following transplantation. Clinical remission occurred immediately after kidney transplantation, and they had no symptoms of UC during 3 and 8 years of follow up periods. Their immunosuppression regimens were cyclosporine, mycophenolate mofetil / azathioprine and prednisone. Conclusion: Kidney transplantation with immunosuppression leads to clinical remission in patients with the inflammatory bowel diseases and ESRD.