A Cross Sectional Survey on Tissue Transglutaminase Auto-Antibodies in Patients with Pulmonary and Extra Pulmonary Tuberculosis
| Author | Iraj Shahramian | en |
| Author | Ameneh Rezaei Keikhaei | en |
| Author | Omolbanin Sargazi Aval | en |
| Author | Mojtaba Delaramnasab | en |
| Author | Ali Bazi | en |
| Orcid | Iraj Shahramian [0000-0002-4134-1405] | en |
| Orcid | Mojtaba Delaramnasab [0000-0002-2958-3671] | en |
| Orcid | Ali Bazi [0000-0003-4872-1352] | en |
| Issued Date | 2020-04-30 | en |
| Abstract | Background: Mycobacterium tuberculosis (TB) is a widespread life-threatening infection worldwide. There is an uncertainty in the association between the emergence of autoimmune antibodies and TB. Objectives: We hereby aimed to screen anti-tissue transglutaminase (anti-tTG) IgA in patients with TB in an Iranian population. Methods: This was a cross sectional study conducted on smear positive TB patients admitted to the Respiratory Diseases Management Center of the city of Zabol, Sistan and Baluchestan Province of Iran during 2017 - 2018. Anti-tTG IgA level was determined using an ELISA kit (Pars Azmoun, Iran). Statistical analyses were performed in SPSS 19 software. Results: Overall, 162 patients were evaluated. Females and males constituted 87 (53.7%) and 75 (46.3%) of the patients respectively. The mean age was 51.7 ± 22.3 years (range of 1 - 83). Afghan patients constituted 16 (9.9%) and the remaining were Iranians. The therapy course was successfully completed in 78 (48.1%) patients, and 67 (41.4%) improved following treatments. Overall, 5 patients had active TB with 2 drug-resistant cases. Pulmonary tuberculosis was diagnosed in 127 (78.4%) while 35 (21.6%) had extra-pulmonary disease. The mean titer of anti-tTG IgA was 22.59 ± 107.7 (range of 0.8 - 940). Overall, 19 (11.9%) of the patients showed elevated levels of the antibody. There was no significant association between anti-tTG IgA titer with neither demographic nor clinical variables. Conclusions: Although anti-tTG IgA antibody test was positive in a relatively high ratio of our patients with TB, the clinical implications of this phenomenon were not significant. | en |
| DOI | https://doi.org/10.5812/archcid.86097 | en |
| Keyword | Tuberculosis | en |
| Keyword | Celiac Disease | en |
| Keyword | Tissue Transglutaminase | en |
| Keyword | <i>Mycobacterium tuberculosis</i> | en |
| Publisher | Brieflands | en |
| Title | A Cross Sectional Survey on Tissue Transglutaminase Auto-Antibodies in Patients with Pulmonary and Extra Pulmonary Tuberculosis | en |
| Type | Research Article | en |
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