The Protective Effects of the <i>Echium amoenum</i> Seed Oil Against Seizures Induced by Pentylenetetrazole
| Author | Hakimeh Gavzan | en |
| Author | Atefeh Araghi | en |
| Author | Ramazan Behzadi | en |
| Orcid | Hakimeh Gavzan [0000-0002-3240-921X] | en |
| Orcid | Atefeh Araghi [0000-0001-6266-3115] | en |
| Issued Date | 2023-08-31 | en |
| Abstract | Background: Many recent studies have documented that polyunsaturated fatty acids (PUFAs) as a safe supplement raise seizure thresholds. However, the evidence of seed oil supplements on seizure susceptibility remains controversial, and among them, Echium seed oil (EO) is a mixture of ω-3 and ω-6 PUFAs. Objectives: This study aimed to test the effects of the sub-chronic administration of EO on intravenous pentylenetetrazole (PTZ) seizure threshold, considering its antioxidant activity and biochemical parameters. Methods: Fifty male mice were divided into five groups (10 in each), including control (no treatment), vehicle (sesame oil), and EO (1, 3, and 5 g/kg) groups. Vehicle and EO were administered p.o. once a day for four weeks. Then, the intravenous PTZ induced-seizure threshold was determined. Finally, the serum concentration of lipid, creatinine, alanine aminotransferase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), and the activity of superoxide dismutase (SOD) was assessed. Results: Pretreatment with EO raised the seizure threshold dose-dependently compared to the vehicle. Pretreatment with EO had no adverse effect on the serum concentration of ALP, AST, ALT, creatinine, high-density lipoprotein (HDL), and low-density lipoprotein (LDL), but at the dosages of 3 and 5 g/kg decreased the concentration of cholesterol, very low-density lipoprotein (VLDL) (P < 0.05), and triglyceride (TG) (P < 0.01). Also, 1 and 3 g/kg of EO improved the activity of SOD (P < 0.01). Conclusions: Pretreatment with EO increases the seizure threshold without negative impacts on the liver and kidney biomarkers, correlated with its positive effects on antioxidant activity and serum lipid profiles. | en |
| DOI | https://doi.org/10.5812/jjnpp-138748 | en |
| Keyword | <i>Echium</i> Seed Oil | en |
| Keyword | Seizure | en |
| Keyword | Biochemical Parameter | en |
| Keyword | SOD | en |
| Publisher | Brieflands | en |
| Title | The Protective Effects of the <i>Echium amoenum</i> Seed Oil Against Seizures Induced by Pentylenetetrazole | en |
| Type | Research Article | en |
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