Treatment of vitamin D deficiency with high-dose vitamin D supplementation and its effect on hematological indices in pregnancy: A secondary analysis of a randomized clinical trial

Abstract

Introduction: There are few studies regarding the treatment of vitamin D deficiency with a high dose of vitamin D and the comparison of serum vitamin D levels and hematological indices (Hemoglobin, Hematocrit, Platelet and Ferritin) in the first and second trimesters of pregnancy. The aim of this study was to evaluate the effect of vitamin D supplementation on these hematological indices in pregnant women with vitamin D deficiency. Materials and Methods: The present study was performed in October 2019 from a secondary and non-predetermined analysis of the effect of vitamin D supplementation and comparison of serum vitamin D levels on blood parameters from a randomized controlled clinical trial. 215 pregnant mothers with vitamin D deficiency were entered in the study and were divided into two treatment groups of 50,000 units and 1000 units. Results: Mean serum levels of Hematocrit, Platelets, and Ferritin after treatment in the treatment groups with 50000 and 1000 unites were 38.6± 3.03 vs 36.05± 2.8 (P