Reed Syndrome; Multiple Cutaneous and Uterine Leiomyomatosis

Abstract

Introduction: Reed syndrome is a rare autosomal dominant disorder with a genetic defect in the fumarate hydratase. Patients with Reed syndrome have multiple cutaneous leiomyomas, uterine leiomyomas or leiomyosarcomas with increased risk of renal carcinoma. Case Presentation: The current study presented a 57-year-old female with multiple cutaneous and uterine leiomyomatosis with a positive family history. She and her family had no evidence of renal carcinoma. Conclusions: Multiple skin leiomyomas could be considered as a cutaneous marker for uterine leiomyomatosis and possible renal cell carcinoma in the familial presentations.