Hydroalcoholic Extract of Ferulago angulata Improves Memory and Pain in Brain Hypoperfusion Ischemia in Rats

Abstract

Background: Cerebral ischemia causes some disorders in behavioral patterns, including memory disorders and pain, which is due to the production of free radicals. Ferulago angulata, known in Iran as chavir, contains some bioactive compounds having antioxidant and free radical-scavenging properties. Objectives: This study aimed to evaluate the effect of two weeks oral administration of hydroalcoholic extract of F. angulate (100, 200 and 400 mg/kg) on pain as well as active and passive avoidance memories after permanent, bilateral common carotid artery occlusion or cerebral ischemia/hypoperfusion in male adult rats. Materials and Methods: In this study, 35 male rats were randomly allocated to test and control groups. To make animal model of permanent cerebral hypoperfusion/ischemia, carotid arteries were ligatured as upper and lower and cut bilaterally. Results: It was found that the administration of 400 mg/kg hydroalcoholic extract of F. angulate for two weeks after brain hypoperfusion ischemia increased the passive avoidance memory (P < 0.001) and latency time of painful tail reflex significantly (P < 0.05). Conclusions: Ferulago angulata extract, because of its antioxidant activities, is probably capable of removing free radicals and oxidant substances from brain and thus it can improve behavioral disorders in brain hypoperfusion ischemia model.