Tuberculosis: Treatment-related Problems and Future Facets
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Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis and is the primary cause of mortality in the world. M. tuberculosis strains are important intracellular pathogens causing infection in oxygen-rich macrophages in the lungs. The emergence of AIDS, declined socioeconomic standards and a lessened emphasis on TB control programs have contributed to the disease resurgence. Resistance of M. tuberculosis strains to anti-TB agents is an increasing problem worldwide. However, powerful new anti-TB drugs with new mechanisms of action have not been developed in the last 40 years, in spite of acute toxicity of repeated dosing of the available anti-TB drugs.