Polyamines Improve Anti-Blood Lactate Accumulation in an Acidosis Rat Model

Abstract

Lactic acidosis (lactate accumulation and pH downfall) occurs in a number of clinical conditions and has deleterious effects on the patient’s survival. Sodium bicarbonate and tromethamine are administrated in these conditions. However, these compounds adjust only the blood pH and do not affected the lactate level. In this study, administration of polyamines was hypothesized as a novel approach for treatment of lactate accumulation. For this purpose, the impact of different polyamines on the experimental model of acidosis was evaluated. In this study, the rats were divided into different groups and lactic acidosis type B was induced in them. Blood lactate was measured before and after acidosis in rats along with polyamines administration. Statistical analysis showed that polyamines such as putrescine, cadaverine and spermidine had significant effects on the lactate level, whereas sodium bicarbonate and tromethamine had no effect on it. These findings supported the advantageous effects of polyamines in treatment of lactate accumulation and can have implications for treatment of acidosis in human. Therefore, polyamines are proposed as an effective treatment for lactic acidosis.