Reversible autonomic dysfunction during antiviral treatment in patients with chronic hepatitis C virus infection
| Author | Janos Osztovits | en |
| Author | Evelin Horvath | en |
| Author | Judit Tax | en |
| Author | Levente Csihi | en |
| Author | Tamas Horvath | en |
| Author | Levente Littvay | en |
| Author | Tamas Toth | en |
| Author | Margit Abonyi | en |
| Author | Peter L Lakatos | en |
| Author | Mark Kollai | en |
| Author | Janos Feher | en |
| Author | Ferenc Szalay | en |
| Author | Hubert E Blum | en |
| Issued Date | 2011-02-28 | en |
| Abstract | Background: The first clinical sign of chronic hepatitis C virus (HCV) infection can be one of the various extrahepatic manifestations. During antiviral treatment, symptoms of HCV-associated neuropathies usually improve, but can also worsen and lead to discontinuation of anti-HCV therapy. Recently, we have reported autonomic dysfunction in patients with HCV infection.Objectives: In the present prospective study, we analyzed the changes of autonomic function during anti-HCV treatment.Patients and Methods: Cardiovagal autonomic function was assessed in 22 HCV RNA-positive, treatment-naive patients by determining heart rate variability (HRV) and baroreflex sensitivity (BRS), at the beginning of treatment and 12, 24 and 48 weeks of antiviral therapy. interferon alfa-2 and ribavirin were given according to the guidelines.Results: Both HRV and BRS time and frequency domain indices decreased after 12 weeks of therapy compared to the pre-treatment values; then the mean±SD values increased significantly by week 24 and continued to improve by week 48 of therapy-253.0±156.1 ms before therapy vs 111.6±81.9 at week 12, and 183.4±169.6 at week 24 vs 211.6±149.1 ms at week 48 for low-frequency HRV index; p | en |
| DOI | https://doi.org/ | en |
| Keyword | Autonomic dysfunction | en |
| Keyword | Antiviral treatment | en |
| Keyword | Hepatitis C virus | en |
| Publisher | Brieflands | en |
| Title | Reversible autonomic dysfunction during antiviral treatment in patients with chronic hepatitis C virus infection | en |
| Type | Research Article | en |