Association of 1661A/G Cytotoxic T lymphocyte Antigen-4 (CTLA-4) Gene Polymorphism With a Clinical Subset of Iranian Children With Systemic Lupus Erythematosus
| Author | Shirin Farivar | en |
| Author | Masoud Dehghan Tezerjani | en |
| Author | Neda Parvini | en |
| Author | Reza Shiari | en |
| Orcid | Shirin Farivar [0000-0002-3277-1163] | en |
| Issued Date | 2014-03-01 | en |
| Abstract | Background: Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is a molecule engaged in regulation of T cells. Polymorphisms in the CTLA-4 gene (CTLA4) are known to be associated with several autoimmune diseases, including Systemic lupus erythematosus. Objectives: To evaluate the potential influences of common SNP in CTLA-4 promoter region (-1661 A/G), a case-control study was performed on Iranian children. Patients and Methods: Genotypes of 31 patients and 50 healthy controls were investigated using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: Our study showed that there were no statistically significant differences in the allele and genotype frequencies of -1661 A/G SNP between patients with SLE and healthy controls (P > 0.05). Conclusions: In conclusion, we found no association between SNP-1661 A/G of the CTLA-4 promoter region and susceptibility to SLE in our population. | en |
| DOI | https://doi.org/10.5812/thrita.16020 | en |
| Keyword | CTLA-4 Antigen | en |
| Keyword | Lupus Erythematosus | en |
| Keyword | Systemic | en |
| Keyword | Polymerase Chain Reaction | en |
| Publisher | Brieflands | en |
| Title | Association of 1661A/G Cytotoxic T lymphocyte Antigen-4 (CTLA-4) Gene Polymorphism With a Clinical Subset of Iranian Children With Systemic Lupus Erythematosus | en |
| Type | Research Article | en |
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