The Antidepressant Activity of <i>Matricaria chamomilla</i> and <i>Melissa officinalis</i> Ethanolic Extracts in Non-Reserpinized and Reserpinized Balb/C Mice
| Author | Abdolrasoul Namjou | en |
| Author | Nasser Yazdani | en |
| Author | Esmail Abbasi | en |
| Author | Mahmoud Rafieian-Kopaei | en |
| Orcid | Abdolrasoul Namjou [0000-0001-5917-2171] | en |
| Orcid | Nasser Yazdani [0000-0003-0507-4597] | en |
| Orcid | Mahmoud Rafieian-Kopaei [0000-0003-3190-7863] | en |
| Issued Date | 2018-11-30 | en |
| Abstract | Background: Matricaria chamomilla and Melissa officinalis have been used as antidepressants in traditional Iranian medicine. Objectives: The aim of this study was to determine the effectiveness of Matricaria chamomilla and Melissa officinalis extracts compared to the classic antidepressant drug, imipramine, in adult non-reserpinized and reserpinized mice through the forced swim test. Methods: In the current experimental study, 80 mice were divided into 10 groups. The first group received normal saline and the second and third groups received 25 and 50 mg/kg of Matricaria chamomilla extract, respectively. The fourth and the fifth groups received 25 and 50 mg/kg of Melissa officinalis extract. The sixth group received imipramine at a dose of 15 mg/kg. The seventh group received 5 mg/kg of reserpine and normal saline. The eighth and ninth groups received 25 and 50 mg/kg of Melissa officinalis and Matricaria chamomilla extracts, respectively. The tenth group was given imipramine through intraperitoneal (I.P) injection. Statistical analyses were performed using one-way analysis of variance (ANOVA) followed by Tukey’s post hoc test in SPSS. Results: Matricaria chamomilla (50 mg/kg), Melissa officinalis (25 mg/kg), and imipramine (15 mg/kg) in non-reserpinized mice significantly decreased the duration of immobility in the forced swim test compared to the control group (P < 0.01). There was a reduction in the duration of immobility in the reserpinized mice administered Matricaria chamomilla at a dose of 50 mg/kg compared to the positive control group (P < 0.01). Conclusions: Matricaria chamomilla and Melissa officinalis have antidepressant effects and may be taken into consideration in treating patients suffering from depression. | en |
| DOI | https://doi.org/10.5812/jjnpp.65549 | en |
| URI | https://brieflands.com/journals/jjnpp/articles/65549 | en |
| Keyword | Depression | en |
| Keyword | Forced Swim Test | en |
| Keyword | <i>Matricaria chamomilla</i> | en |
| Keyword | <i>Melissa officinalis</i> | en |
| Keyword | Balb/C | en |
| Publisher | Brieflands | en |
| Title | The Antidepressant Activity of <i>Matricaria chamomilla</i> and <i>Melissa officinalis</i> Ethanolic Extracts in Non-Reserpinized and Reserpinized Balb/C Mice | en |
| Type | Research Article | en |
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