Induction of a rat model of Alzheimer’s disease by amyloid-β did not change short term synaptic plasticity in CA1 area of hippocampus
| Author | Jafar Doost mohammad pour | en |
| Author | Narges hosseinmardi | en |
| Author | Mahyar Janahmadi | en |
| Author | Shima Ebrahimi | en |
| Author | Yaghoub Fathollahi | en |
| Author | Fereshteh Motamedi | en |
| Issued Date | 2014-12-31 | en |
| Abstract | Introduction: Alzheimer’s disease (AD) has been suggested to be a form of neuroplasticity failure. In addition to long term maladaptive changes in synaptic function, short term synaptic plasticity that has a role in information processing can be affected in AD that was investigated in this study. Materials and Methods: Field excitatory post synaptic potential (fEPSP) from Stratum radiatum of CA1 neurons were recorded following Schaffer collateral stimulation in a rat model of Alzheimer’s disease (AD). 1 µl of Aβ 1-42 (5µg/µl) and 1 µl of ibotenic acid (5µg/µl) were injected in dorsal hippocampus of male rats for AD induction. For examining the short-term synaptic plasticity, paired pulse stimulations with inter pulse interval (IPI) of 20, 80, and 200 ms were applied and paired pulse index (PPI) was calculated. Results: Results showed that although AD induction decreased basal synaptic responses especially at high stimulus intensity, this change was not significant (ANOVA P>0.05). Also there were no significant changes in PPI of AD rats at different IPIs including 20 ms (%40.4±4.68, n=5), 80 ms (%129.8±4.1, n=5), and 200 ms (%129±6.8, n=5) in comparison with control ones (%75.2±5.08, %138±7.56, %108.4±2.09 respectively, n=5, P>0.05, unpaired t-test). Conclusion: Such results indicate that hippocampal Aβ treatment does not lead to impairment of basal synaptic response and short term synaptic plasticity | en |
| DOI | https://doi.org/ | en |
| Keyword | Alzheimer disease | en |
| Keyword | Amyloid beta-protein | en |
| Keyword | Short term synaptic plasticity | en |
| Keyword | Hippocampus | en |
| Keyword | Field potential recording | en |
| Keyword | بیماری آلزایمر | en |
| Keyword | پروتئین آمیلوئید بتا | en |
| Keyword | شکل پذیری سیناپسی کوتاه مدت | en |
| Keyword | هیپوکمپ | en |
| Keyword | ثبت پتانسیل میدانی | en |
| Publisher | Brieflands | en |
| Title | Induction of a rat model of Alzheimer’s disease by amyloid-β did not change short term synaptic plasticity in CA1 area of hippocampus | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- article-1-2183-fa.pdf.pdf
- Size:
- 529.24 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF