The effects of Ropivacaine and its Combination with Dexmedetomidine and Dexamethasone on Neural Apoptosis
| Author | Mohammadreza Moshari | en |
| Author | Behnam Hosseini | en |
| Author | Ali Dabbagh | en |
| Author | Faramarz Mosaffa | en |
| Author | Shideh Dabir | en |
| Author | seyed mohammad seyed alshohadaei | en |
| Author | Fereshteh Baghizadeh | en |
| Orcid | Ali Dabbagh [0000-0003-4344-8131] | en |
| Orcid | Shideh Dabir [0000-0002-9726-6045] | en |
| Issued Date | 2020-09-30 | en |
| Abstract | Background: Neurotoxicity effects of anesthetics in different age groups is a major concern regarding neural injuries. It is reasonable to recognize the neurotoxicity risks of anesthetic drugs and their combinations. Materials and Methods: A total of 16 mice (Mus musculus) weighing 22 to 30 gr were randomly divided into four drug groups (control, Ropivacaine, Ropivacaine + Dexmedetomidine, Ropivacaine + Dexamethasone). 24 hours after unilateral injection of drugs into the femoral nerve of mice, the mice were killed and their femoral nerve was removed. Hematoxylin-eosin tissue staining was used to evaluate changes in the effects of the drugs, and nerve samples were extracted to measure TLR4 and caspase 3 expressions. After Western blotting, the protein expression level was checked between different groups. Results: Ropivacaine in combination with dexamethasone caused less damage to the rat nerve cells. The combination of ropivacaine with dexamethasone (p=0.53 and p=0.46) compared to the combination of ropivacaine with dexmedetomidine relatively had better results in terms of cytotoxicity. Conclusion: A combination of ropivacaine with dexamethasone reduces neurotoxicity risk. | en |
| DOI | https://doi.org/10.22037/jcma.v5i3.30086 | en |
| URI | https://brieflands.com/journals/jcma/articles/149619 | en |
| Keyword | Ropivacaine | en |
| Keyword | Dexmedetomidine | en |
| Keyword | Dexamethasone | en |
| Keyword | Toll like receptors | en |
| Keyword | Glyceraldehyde 3-phosphate dehydrogenase | en |
| Keyword | Cysteine-aspartic acid protease | en |
| Publisher | Brieflands | en |
| Title | The effects of Ropivacaine and its Combination with Dexmedetomidine and Dexamethasone on Neural Apoptosis | en |
| Type | Original Articles | en |
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