Jet lag in military and civil aviation

Abstract

Background: Physiologic or behavioral cycles are generated by an internal pacemaker with an oscillatory frequency of approximately 24. 2 hours which named Circadian Rhythm. This internal pacemaker is locate at hypothalamus as suprachiasmatic nucleus and it Controls sleep/wake cycle, with wakefulness commonly promoted during daylight hours and sleep promoted during evening hours. The Aim of This article is providing a framework for understanding the biological basis of jet lag and for recommending management strategies. Understanding jet lag can help us address the broader problem of circadian misalignment, which has increasingly been associated with increased risk for cancer(Colorectal and Breast), metabolic disease, cardiovascular dysfunction, mood disorders (Depression), and cognitive decline.