Transforming Growth Factor β1 (TGF-β1) in the Sera of Postmenopausal Osteoporotic Females
| Author | Aazam Faraji | en |
| Author | Shabnam Abtahi | en |
| Author | Abbas Ghaderi | en |
| Author | Alamtaj Samsami Dehaghani | en |
| Issued Date | 2016-10-01 | en |
| Abstract | Background: Postmenopausal osteoporosis is a major cause of morbidity in postmenopausal females. Transforming growth factor β1 (TGF-β1) and interleukin 18 (IL-18) play complex roles in normal bone metabolism, and in pathophysiology of postmenopausal osteoporosis. Objectives: The aim of this study was to design an analytic cross sectional study in order to further clarify the role of TGF-β1 and IL-18 in osteoporosis of postmenopausal females. Methods: A cross sectional study including 65 postmenopausal osteoporotic females as cases and 69 postmenopausal females of similar age without osteoporosis as controls was conducted. Dual energy X-ray absorptiometry (DXA) was used to determine bone mass density (BMD) of participants and T-scoring was applied to establish whether the patient has osteoporosis or not. Serum TGF-β1 and IL-18 levels were measured by quantitative sandwich Enzyme linked immunosorbent assay (ELISA). Results: Serum TGF-β1 levels were significantly higher in osteoporotic postmenopausal females than non-osteoporotic individuals (23.8 vs. 15.8 ng/mL; P = 0.009). There was no difference between IL-18 levels in the sera of osteoporotic and non-osteoporotic postmenopausal females in this study. There was a positive correlation between body mass index (BMI) and serum level of TGF-β1 (P = 0.04). Conclusions: Our study demonstrated that TGF-β1 serum levels is higher in osteoporotic postmenopausal females than non-osteoporotic ones, and probably aberrant increase in TGF-β1 in postmenopausal females can result in uncoupled bone resorption and formation, which leads to osteoporosis. | en |
| DOI | https://doi.org/10.5812/ijem.36511 | en |
| URI | https://brieflands.com/journals/ijem/articles/17737 | en |
| Keyword | TGF-β1 | en |
| Keyword | IL-18 | en |
| Keyword | Osteoporosis | en |
| Keyword | Postmenopausal | en |
| Publisher | Brieflands | en |
| Title | Transforming Growth Factor β1 (TGF-β1) in the Sera of Postmenopausal Osteoporotic Females | en |
| Type | Research Article | en |
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