Hepatic Arterial Infusion Chemotherapy with Cisplatin for TACE-Refractory or -Ineligible Hepatocellular Carcinoma with Child-Pugh Score of 8 or Above
| Author | Michihisa Moriguchi | en |
| Author | Takeshi Aramaki | en |
| Author | Kiichiro Yoza | en |
| Author | Kenji Iwai | en |
| Author | Rui Sato | en |
| Author | Koiku Asakura | en |
| Author | Masahiro Endo | en |
| Author | Mitsuhiro Furuta | en |
| Author | Yuya Seko | en |
| Author | Yoshito Itoh | en |
| Issued Date | 2017-02-01 | en |
| Abstract | Background: This study aimed to retrospectively assess the safety and usefulness of hepatic arterial infusion chemotherapy (HAIC) with cisplatin in patients with hepatocellular carcinoma (HCC) and Child-Pugh (C-P) score ≥ 8, who were refractory to or ineligible for transcatheter arterial chemoembolization (TACE). Methods: In this study, 28 cisplatin-naïve patients with HCC, C-P score ≥ 8, and no evidence of extrahepatic lesions were treated using HAIC with cisplatin between July 2004 and July 2013. Results: Of 28 patients, 10 were refractory to TACE and 18 ineligible for TACE. In terms of C-P score, 17 patients had a score of 8, 6 a score of 9, and 5 a score of 10. The injected dose of cisplatin was reduced in 64.3% of cases. The overall response rate was 10.7%, with a disease control rate of 35.7%. Overall, median survival time (MST) and progression-free survival were 186 and 80 days, respectively. In patients with macroscopic vascular invasion (MVI-positive; n = 9), these values decreased to 161 and 72 days, respectively; while they increased to 341 and 87 days, respectively, in MVI-negative patients (n = 19). Patients achieving partial response (PR) and stable disease (SD) status as well as those achieving SD status showed significantly better survival than patients with progressive disease (PD status): PR + SD vs. PD: MST = 447 vs. 123 days, P < 0.001; SD vs. PD: MST = 447 vs. 123 days, P = 0.001). No serious adverse event or treatment-related death occurred. Conclusions: HAIC with cisplatin can be safely administered in patients with HCC and C-P score ≥ 8, who are TACE-refractory or -ineligible. An extended survival time is expected when the treatment outcome is either SD or more favorable. | en |
| DOI | https://doi.org/10.5812/hepatmon.43627 | en |
| Keyword | Chemotherapy | en |
| Keyword | Cisplatin | en |
| Keyword | Intraarterial | en |
| Keyword | Liver Cancer | en |
| Publisher | Brieflands | en |
| Title | Hepatic Arterial Infusion Chemotherapy with Cisplatin for TACE-Refractory or -Ineligible Hepatocellular Carcinoma with Child-Pugh Score of 8 or Above | en |
| Type | Research Article | en |
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