Magnesium Sulfate versus HCG (Human Chorionic Gonadotropin) in Suppression of Preterm Labor

Abstract

Introduction: Preterm labor is defined as delivery before 37completed weeks of pregnancy. Since 10% of total labors are preterm and 70% of infants’ mortality is due to this problem, preterm labor is an important problem in obstetrics, midwifery and pediatrics. So that different treatments have been employed in order to suppress preterm labor from several years ago. Magnesium sulfate is often used as a first - line in suppressing of preterm labor, although its maternal and neonatal side effects are common, in best of conditions only 24-48 hours delays of labor, and randomized clinical trial studies have shown that in suppression of preterm labor it is as effective as placebo. On the other hand because of known ability of Human Chorionic Gonadotropin (HCG) in suppression of contractions in muscles detached from human myometer (in vitro), and safety of this drug in pregnancy, we take a decision that compare the ability of Magnesium Sulfate with HCG in suppression of preterm labor.