Early Conversion to Tacrolimus Vs Cyclosporine Continuation in Normally Functioning Kidney Allograft: A Single-Center Study
| Author | Laya Azizzadeh | en |
| Author | Seyed Amirhossein Fazeli | en |
| Author | Farshad Hashemian | en |
| Author | Sanaz Dehghani | en |
| Author | Seyedeh Samaneh Ahmadi | en |
| Author | Gholamreza Pourmand | en |
| Issued Date | 2020-07-31 | en |
| Abstract | This study evaluated the effectiveness of early pre-emptive conversion from cyclosporine to tacrolimus in kidney transplant patients with normal graft function and in the absence of adverse effects of the initial cyclosporine. A historical cohort study of 166 patients who received deceased-donor kidney transplant between 2011 to 2017 was conducted. All the patients had been treated with cyclosporine (Sandimmune®) during their immediate post-transplantation period. At the time of hospital discharge, the patients were divided into 2 groups: patients with continued cyclosporine (Sandimmune®) treatment (n = 125) and the patients whose treatments converted from cyclosporine to tacrolimus (Prograf®) at discharge (n = 41). The 1-year graft function (p = 0.074), acute rejection (p = 0.566), and graft loss (p = 0.566) were not significantly different between two groups. The patients on tacrolimus had lower levels of cholesterol (p = 0.002) and diastolic blood pressure (p = 0.015). The long-term follow-up showed no significant difference in graft loss (p = 0.566). The patients received tacrolimus had higher all-cause mortality within the first year posttransplantation (p = 0.002) as well as long-term follow-up (p = 0.001). The continuation of initial cyclosporine might be a good option when the graft function is acceptable and the adverse effects are absent. | en |
| DOI | https://doi.org/10.22037/ijpr.2020.113220.14174 | en |
| Keyword | Graft | en |
| Keyword | Transplantation | en |
| Keyword | Calcineurin inhibitors | en |
| Keyword | Kidney | en |
| Keyword | Immunosuppressive | en |
| Publisher | Brieflands | en |
| Title | Early Conversion to Tacrolimus Vs Cyclosporine Continuation in Normally Functioning Kidney Allograft: A Single-Center Study | en |
| Type | Research Article | en |